8 RESULTS
COMMENT Tau has a multitude of phosphorylation sites, many of which are increased in pathology, but the differential significance of specific p-tau variants in the AD pathogenic cascade is largely unknown. Recent reports indicate the potential of tau phosphorylat
COMMENT GVBs, as their core is immunopositive for necrosomes. As the authors and commentators indicate, caution
COMMENT We completely agree that the elegant design of the Sephin compound explains the lack of side effects. We thought it relevant to point out to readers that inhibition of eIF2α phosphorylation via genetic deletion or pharmacological inhibition of PERK protec
COMMENT The paper by Indrajit Das and colleagues supports accumulating evidence that regulating the phosphorylation or dephosphorylation of eukaryotic initiation factor 2α (eIF2α) is a potential therapeutic approach for treating neurodegenerative diseases. Regula
COMMENT The exciting paper by Ma et al. contributes to the accumulating evidence that PERK is involved in neurodegeneration and is potentially a therapeutic target (reviewed in (1)). Our group reported previously the activation of the unfolded protein response (U
COMMENT In this paper, Hu and colleagues explore the role of the unfolded protein response (UPR) in neurodegeneration of retinal ganglion cells in the context of traumatic optic nerve injury and glaucoma. The data presented may indicate that selective activation
COMMENT This tremendous collaborative effort has yielded very exciting results that will have great impact on tauopathy research. Here we want to highlight the association of risk for PSP with SNPs in the EIF2AK3 region, which encodes the endoplasmic reticulum (E
COMMENT Our lab previously reported activation of the UPR in AD neurons (Hoozemans et al., 2005). In the current paper, Ferreiro et al. show induction of BiP levels, as well as decreased pro-caspase-12 levels induced by Aβ1-40. This may indicate that the ER stres
